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Symbol
Name
ID

Brca1
breast cancer 1, early onset
MGI:104537

Phenotype annotations related to reproductive system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Hypogonadism

Hypospadias

Abnormal preputium morphology

Abnormal testis morphology

Absent testis

Cryptorchidism

Prostate cancer

Dysgerminoma

Ovarian carcinoma

Ovarian papillary adenocarcinoma

Abnormality of the uterus

Cervix cancer

Bicornuate uterus

Uterine leiomyosarcoma

Azoospermia

Decreased fertility in males

Disease(s) Associated with BRCA1

cervical cancer

colorectal cancer

Fanconi anemia

ovarian cancer

pancreatic cancer

prostate cancer

Mouse Phenotypes		reproductive system phenotype	azoospermia	abnormal mammary gland growth during pregnancy	abnormal ovary morphology	ovary cyst	small testis	arrest of spermatogenesis	empty decidua capsularis	male infertility
Availability	Mouse Genotype	reproductive system phenotype	azoospermia	abnormal mammary gland growth during pregnancy	abnormal ovary morphology	ovary cyst	small testis	arrest of spermatogenesis	empty decidua capsularis	male infertility
	Brca1^tm1Arge/Brca1^tm1Arge
	Brca1^tm2Arge/Brca1^tm2Arge
	Brca1^tm2Rjbr/Brca1^tm2Rjbr
	Brca1^tm3.1Rjbr/Brca1^tm3.1Rjbr
	Brca1^tm4.1Rjbr/Brca1^tm4.1Rjbr	*
	Brca1^tm1Brn/Brca1^tm1Brn (conditional)
	Brca1^tm2Cxd/Brca1^tm2Cxd Tg(Fshr-cre)1Ldu/0 (conditional)
	Brca1^tm1Cxd/Brca1^tm2Cxd Tg(Wap-cre)11738Mam/0 (conditional)
	Brca1^tm1Cxd/Brca1^tm2Cxd Tg(MMTV-cre)4Mam/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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